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Symbol
Name
ID

Elane
elastase, neutrophil expressed
MGI:2679229

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating antibody level	Eosinophilia	Neutropenia	Cyclic neutropenia	Congenital agranulocytosis	Monocytosis	Acute monocytic leukemia	Recurrent bacterial infections
Disease(s) Associated with ELANE	Increased circulating antibody level	Eosinophilia	Neutropenia	Cyclic neutropenia	Congenital agranulocytosis	Monocytosis	Acute monocytic leukemia	Recurrent bacterial infections
cyclic hematopoiesis
severe congenital neutropenia 1

Mouse Phenotypes		immune system phenotype	abnormal neutrophil physiology	impaired neutrophil recruitment	decreased tumor necrosis factor secretion	abnormal inflammatory response	decreased susceptibility to bacterial infection induced morbidity/mortality	increased susceptibility to bacterial infection	increased susceptibility to bacterial infection induced morbidity/mortality	increased susceptibility to infection induced morbidity/mortality
Availability	Mouse Genotype	immune system phenotype	abnormal neutrophil physiology	impaired neutrophil recruitment	decreased tumor necrosis factor secretion	abnormal inflammatory response		increased susceptibility to bacterial infection
	Elane^M1Btlr/Elane^M1Btlr
	Elane^tm1(cre)Roes/Elane^tm1(cre)Roes
	Elane^tm1Link/Elane^tm1Link	*
	Elane^tm1Sds/Elane^tm1Sds

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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